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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1735
http://purl.obolibrary.org/obo/NCIT_C1735
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|---|---|
| Preferred Name | Methotrexate Sodium |
| Definitions |
The sodium salt of methotrexate, an antimetabolite with antineoplastic and immunomodulating properties. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant properties. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The sodium salt of methotrexate, an antimetabolite with antineoplastic and immunomodulating properties. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant properties. (NCI04) |
|---|---|
| prefLabel | Methotrexate Sodium
|
| label | Methotrexate Sodium
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| CHEBI_ID | CHEBI:50679
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| PDQ_Closed_Trial_Search_ID | 41719
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| code | C1735
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| Has_Target | |
| prefixIRI | NCIT:C1735
|
| in_subset |
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| Display_Name | Methotrexate Sodium
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| Preferred_Name | Methotrexate Sodium
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| FDA_UNII_Code | 3IG1E710ZN
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C20H20N8O5.2Na
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| Maps_To | Methotrexate Sodium
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| CAS_Registry | 7413-34-5
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| NCI_Drug_Dictionary_ID | 41719
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| Legacy Concept Name | Sodium_Methotrexate
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 41719
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C0949359
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