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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C173371
http://purl.obolibrary.org/obo/NCIT_C173371
|
|---|---|
| Preferred Name | Interleukin-12-Fc Fusion Protein DF6002 |
| Definitions |
A fusion protein composed of human interleukin-12 (IL-12) fused to a Fc fragment, with potential immunomodulatory and antineoplastic activities. Upon administration of IL-12-Fc fusion protein DF6002, the IL-12 moiety binds to the IL-12 receptor. This may activate the immune system by promoting the secretion of interferon-gamma, activating natural killer cells (NKs), and inducing cytotoxic T-lymphocyte (CTL) responses, which may result in both decreased tumor cell proliferation and enhanced immune-mediated destruction of tumor cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A fusion protein composed of human interleukin-12 (IL-12) fused to a Fc fragment, with potential immunomodulatory and antineoplastic activities. Upon administration of IL-12-Fc fusion protein DF6002, the IL-12 moiety binds to the IL-12 receptor. This may activate the immune system by promoting the secretion of interferon-gamma, activating natural killer cells (NKs), and inducing cytotoxic T-lymphocyte (CTL) responses, which may result in both decreased tumor cell proliferation and enhanced immune-mediated destruction of tumor cells. |
|---|---|
| prefLabel | Interleukin-12-Fc Fusion Protein DF6002
|
| label | Interleukin-12-Fc Fusion Protein DF6002
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| NCI_META_CUI | CL1407203
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| PDQ_Closed_Trial_Search_ID | 801838
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| code | C173371
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| Has_Target | |
| prefixIRI | NCIT:C173371
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| in_subset |
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| Display_Name | Interleukin-12-Fc Fusion Protein DF6002
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| Preferred_Name | Interleukin-12-Fc Fusion Protein DF6002
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| Contributing_Source | CTRP
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| Maps_To | Interleukin-12-Fc Fusion Protein DF6002
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| NCI_Drug_Dictionary_ID | 801838
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 801838
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| Semantic_Type | Pharmacologic Substance
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