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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C17336
http://purl.obolibrary.org/obo/NCIT_C17336
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|---|---|
| Preferred Name | T-Cell-Specific Surface Glycoprotein CD28 |
| Definitions |
T-cell-specific surface glycoprotein CD28 (220 aa, ~25 kDa) is encoded by the human CD28 gene. This protein is involved in the survival and activation of T-lymphocytes.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | T-cell-specific surface glycoprotein CD28 (220 aa, ~25 kDa) is encoded by the human CD28 gene. This protein is involved in the survival and activation of T-lymphocytes. |
|---|---|
| prefLabel | T-Cell-Specific Surface Glycoprotein CD28
|
| label | T-Cell-Specific Surface Glycoprotein CD28
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| code | C17336
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| prefixIRI | NCIT:C17336
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| OMIM_Number | 186760
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| in_subset | |
| Display_Name | T-Cell-Specific Surface Glycoprotein CD28
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| Preferred_Name | T-Cell-Specific Surface Glycoprotein CD28
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| Contributing_Source | CTRP
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| Swiss_Prot | P10747
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| Legacy Concept Name | CD28_Antigen
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| DesignNote | CD28 encodes a highly glycosylated membrane protein with homology to the Ig superfamily. It also shares significant sequence identity with CTLA-4. Both bind the same ligands, however CTLA-4 binds to B7 with a greater affinity. B7 antigen-presenting cells regulate T-cell activation by delivering antigen-independent stimulatory signals through CD28 and inhibitory signals through CTLA-4. CD28 is found on the membrane of resting T-cells. CD28 undergoes tyrosine phosphorylation after interacting with its ligand, B7. Phosphorylation in the cytoplasmic domain of CD28 allows the recruitment of signaling proteins such as PI3K, GRB2, and GADS via their SH2 domains. (OMIM)
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| type | |
| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Receptor
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| UMLS_CUI | C0075747
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