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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C173076
http://purl.obolibrary.org/obo/NCIT_C173076
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|---|---|
| Preferred Name | Anti-HER2 Antibody Conjugated Natural Killer Cells ACE1702 |
| Definitions |
An off-the-shelf preparation of natural killer (NK) cells conjugated to a monoclonal antibody targeting human epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2), with potential antineoplastic activity. Upon administration of anti-HER2 antibody conjugated natural killer cells ACE1702, the antibody moiety targets and binds to HER2 on tumor cells, which may lead to cell lysis of HER2-expressing tumor cells by the NK cells. HER2, a tyrosine kinase receptor, is overexpressed by many cancer cell types.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An off-the-shelf preparation of natural killer (NK) cells conjugated to a monoclonal antibody targeting human epidermal growth factor receptor 2 (EGFR2; HER2; ErbB2), with potential antineoplastic activity. Upon administration of anti-HER2 antibody conjugated natural killer cells ACE1702, the antibody moiety targets and binds to HER2 on tumor cells, which may lead to cell lysis of HER2-expressing tumor cells by the NK cells. HER2, a tyrosine kinase receptor, is overexpressed by many cancer cell types. |
|---|---|
| prefLabel | Anti-HER2 Antibody Conjugated Natural Killer Cells ACE1702
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| label | Anti-HER2 Antibody Conjugated Natural Killer Cells ACE1702
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| NCI_META_CUI | CL1406967
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| PDQ_Closed_Trial_Search_ID | 802031
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| code | C173076
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| Has_Target | |
| prefixIRI | NCIT:C173076
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| in_subset |
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| Display_Name | Anti-HER2 Antibody Conjugated Natural Killer Cells ACE1702
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| Preferred_Name | Anti-HER2 Antibody Conjugated Natural Killer Cells ACE1702
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| Contributing_Source | CTRP
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| Maps_To | Anti-HER2 Antibody Conjugated Natural Killer Cells ACE1702
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| NCI_Drug_Dictionary_ID | 802031
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 802031
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| Semantic_Type | Pharmacologic Substance
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