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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C17281
http://purl.obolibrary.org/obo/NCIT_C17281
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|---|---|
| Preferred Name | Tumor Necrosis Factor Receptor Superfamily Member 5 |
| Definitions |
Tumor necrosis factor receptor superfamily member 5 (277 aa, ~31 kDa) is encoded by the human CD40 gene. This protein is involved in the positive regulation of immunoglobulin secretion.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Tumor necrosis factor receptor superfamily member 5 (277 aa, ~31 kDa) is encoded by the human CD40 gene. This protein is involved in the positive regulation of immunoglobulin secretion. |
|---|---|
| label | Tumor Necrosis Factor Receptor Superfamily Member 5
|
| prefLabel | Tumor Necrosis Factor Receptor Superfamily Member 5
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| Legacy Concept Name | CD40L_Receptor
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| in_subset | |
| Preferred_Name | Tumor Necrosis Factor Receptor Superfamily Member 5
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| Display_Name | Tumor Necrosis Factor Receptor Superfamily Member 5
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| Swiss_Prot | P25942
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| DesignNote | Related to NGFR, TNFR-alpha, and CD27, CD40 is a 50 kD glycophosphoprotein homodimer expressed on mature B-cells, but not on plasma cells, that plays an important role in B-cell development and activation. These CD40 homologies imply that its ligand may be a soluble factor and that CD40 is a member of the cytokine receptor family. CD40/CD40-ligand interactions play a critical role in the activation of humoral and cell-mediated immune responses. CD40-dependent activation of B-cells is important for generation of memory B-cells within germinal centers. (OMIM)
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| UMLS_CUI | C0054959
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| prefixIRI | NCIT:C17281
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| Contributing_Source | CTRP
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| subClassOf | |
| code | C17281
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| type | |
| OMIM_Number | 109535
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Receptor
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