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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1725
http://purl.obolibrary.org/obo/NCIT_C1725
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|---|---|
| Preferred Name | Tyrosine Kinase Inhibitor SU5402 |
| Definitions |
An indolinone-based small molecule selective tyrosine kinase inhibitor with potential antineoplastic activity. SU5402 blocks the activities of vascular endothelial growth factor receptors (VEGFR) and fibroblast growth factor 1 (FGFR1) via competing with ATP for the specific binding site within the catalytic domain of these receptors. This agent was shown to inhibit cell growth, decrease cell viability in dose-dependent manner, and induce apoptosis.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An indolinone-based small molecule selective tyrosine kinase inhibitor with potential antineoplastic activity. SU5402 blocks the activities of vascular endothelial growth factor receptors (VEGFR) and fibroblast growth factor 1 (FGFR1) via competing with ATP for the specific binding site within the catalytic domain of these receptors. This agent was shown to inhibit cell growth, decrease cell viability in dose-dependent manner, and induce apoptosis. |
|---|---|
| prefLabel | Tyrosine Kinase Inhibitor SU5402
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| label | Tyrosine Kinase Inhibitor SU5402
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| CHEBI_ID | CHEBI:63449
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| code | C1725
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| prefixIRI | NCIT:C1725
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| in_subset | |
| Preferred_Name | Tyrosine Kinase Inhibitor SU5402
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| Maps_To | Tyrosine Kinase Inhibitor SU5402
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| Legacy Concept Name | SU5402
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0538431
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