Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C17242
http://purl.obolibrary.org/obo/NCIT_C17242
Preferred Name

Urokinase-Type Plasminogen Activator
Definitions
Urokinase-type plasminogen activator (431 aa, ~49 kDa) is encoded by the human PLAU gene. This protein plays a role in both cell surface receptor binding and the cleavage of plasminogen between Arg-580 and Val-581 to form the fibrinolytic enzyme plasmin.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

Urokinase-type plasminogen activator (431 aa, ~49 kDa) is encoded by the human PLAU gene. This protein plays a role in both cell surface receptor binding and the cleavage of plasminogen between Arg-580 and Val-581 to form the fibrinolytic enzyme plasmin.
prefLabel
Urokinase-Type Plasminogen Activator
label
Urokinase-Type Plasminogen Activator
NCI_META_CUI
CL790344
code
C17242
prefixIRI
NCIT:C17242
OMIM_Number
191840
in_subset
Display_Name
Urokinase-Type Plasminogen Activator
Preferred_Name
Urokinase-Type Plasminogen Activator
Contributing_Source
CTRP
Swiss_Prot
P00749
Legacy Concept Name
Urokinase
DesignNote
Urokinase-type plasminogen activator is found in high and low molecular mass forms. Each form is comprised of two chains, A and B. The high molecular mass form contains a long chain A which is cleaved to yield a short chain A. (UniProt)
type
ALT_DEFINITION
An enzyme that is made in the kidney and found in the urine. A form of this enzyme is made in the laboratory and used to dissolve blood clots or to prevent them from forming.
subClassOf
Semantic_Type
Amino Acid, Peptide, or Protein
Enzyme
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