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Biological and Environmental Research Ontology
| Id | http://purl.obolibrary.org/obo/NCIT_C172395
http://purl.obolibrary.org/obo/NCIT_C172395
|
|---|---|
| Preferred Name | LMP2-specific T Cell Receptor-transduced Autologous T-lymphocytes |
| Definitions |
A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector encoding a T-cell receptor (TCR) specific for human leukocyte antigen (HLA)-A02:01/24:02/11:01-restricted Epstein-Barr virus (EBV) latent membrane proteins (LMP) 1 and 2, and EBV nuclear antigen 1 (EBNA1), with potential antineoplastic activity. Upon administration, the autologous LMP1/LMP2/EBNA1-specific, HLA-A02:01/24:02/11:01-restricted TCR-expressing T-lymphocytes YT-E001 recognize and bind to HLA-presented EBV peptides, which may promote cell death and inhibit the growth of tumor cells expressing LMP1, LMP2 or EBNA1. LMP1, LMP2, and EBNA1 are expressed in various, EBV-associated malignancies, including nasopharyngeal cancer and EBV-positive Hodgkin lymphoma.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector encoding a T-cell receptor (TCR) specific for human leukocyte antigen (HLA)-A02:01/24:02/11:01-restricted Epstein-Barr virus (EBV) latent membrane proteins (LMP) 1 and 2, and EBV nuclear antigen 1 (EBNA1), with potential antineoplastic activity. Upon administration, the autologous LMP1/LMP2/EBNA1-specific, HLA-A02:01/24:02/11:01-restricted TCR-expressing T-lymphocytes YT-E001 recognize and bind to HLA-presented EBV peptides, which may promote cell death and inhibit the growth of tumor cells expressing LMP1, LMP2 or EBNA1. LMP1, LMP2, and EBNA1 are expressed in various, EBV-associated malignancies, including nasopharyngeal cancer and EBV-positive Hodgkin lymphoma. |
|---|---|
| prefLabel | LMP2-specific T Cell Receptor-transduced Autologous T-lymphocytes
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| label | LMP2-specific T Cell Receptor-transduced Autologous T-lymphocytes
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| NCI_META_CUI | CL1406351
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| PDQ_Closed_Trial_Search_ID | 801627
|
| code | C172395
|
| prefixIRI | NCIT:C172395
|
| in_subset | |
| Preferred_Name | LMP2-specific T Cell Receptor-transduced Autologous T-lymphocytes
|
| Maps_To | LMP2-specific T Cell Receptor-transduced Autologous T-lymphocytes
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| NCI_Drug_Dictionary_ID | 801627
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 801627
|
| Semantic_Type |
Pharmacologic Substance
Cell
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