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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C172198
http://purl.obolibrary.org/obo/NCIT_C172198
|
|---|---|
| Preferred Name | Anti-HER2 Monoclonal Antibody HLX22 |
| Definitions |
A humanized immunoglobulin (lg) G1 monoclonal antibody directed against the human epidermal growth factor receptor 2 (HER2), with potential immunomodulating and antineoplastic activity. Upon administration, anti-HER2 monoclonal antibody HLX22 targets and binds to HER2 on tumor cell surface. This may induce a cytotoxic T-lymphocyte (CTL) response as well as an antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor cells that overexpress HER2. HER2, a tyrosine kinase receptor, is overexpressed by many cancer cell types.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A humanized immunoglobulin (lg) G1 monoclonal antibody directed against the human epidermal growth factor receptor 2 (HER2), with potential immunomodulating and antineoplastic activity. Upon administration, anti-HER2 monoclonal antibody HLX22 targets and binds to HER2 on tumor cell surface. This may induce a cytotoxic T-lymphocyte (CTL) response as well as an antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor cells that overexpress HER2. HER2, a tyrosine kinase receptor, is overexpressed by many cancer cell types. |
|---|---|
| prefLabel | Anti-HER2 Monoclonal Antibody HLX22
|
| label | Anti-HER2 Monoclonal Antibody HLX22
|
| NCI_META_CUI | CL1406092
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| PDQ_Closed_Trial_Search_ID | 801537
|
| code | C172198
|
| prefixIRI | NCIT:C172198
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| in_subset | |
| Preferred_Name | Anti-HER2 Monoclonal Antibody HLX22
|
| Maps_To | Anti-HER2 Monoclonal Antibody HLX22
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| NCI_Drug_Dictionary_ID | 801537
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 801537
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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