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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C172103
http://purl.obolibrary.org/obo/NCIT_C172103
|
|---|---|
| Preferred Name | Autologous CD19 CAR-expressing CD4+/CD8+ T-cells MB-CART19.1 |
| Definitions |
A preparation of CD4+ and CD8+ autologous T-lymphocytes transduced with the lentiviral vector pLTG1563 expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous CD19 CAR-expressing CD4+/CD8+ T-cells MB-CART19.1 are directed to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A preparation of CD4+ and CD8+ autologous T-lymphocytes transduced with the lentiviral vector pLTG1563 expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous CD19 CAR-expressing CD4+/CD8+ T-cells MB-CART19.1 are directed to and induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. |
|---|---|
| prefLabel | Autologous CD19 CAR-expressing CD4+/CD8+ T-cells MB-CART19.1
|
| label | Autologous CD19 CAR-expressing CD4+/CD8+ T-cells MB-CART19.1
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| NCI_META_CUI | CL1406220
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| PDQ_Closed_Trial_Search_ID | 801342
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| code | C172103
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| prefixIRI | NCIT:C172103
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| in_subset | |
| Preferred_Name | Autologous CD19 CAR-expressing CD4+/CD8+ T-cells MB-CART19.1
|
| Maps_To | Autologous CD19 CAR-expressing CD4+/CD8+ T-cells MB-CART19.1
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| NCI_Drug_Dictionary_ID | 801342
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 801342
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| Semantic_Type |
Pharmacologic Substance
Cell
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| Delete | Subject | Author | Type | Created |
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