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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C17199
http://purl.obolibrary.org/obo/NCIT_C17199
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|---|---|
| Preferred Name | Thymidylate Synthase |
| Definitions |
Thymidylate synthetase protein (312 aa, ~36 kDa) is encoded by the human TYMS gene. The protein is a conserved transferase enzyme that catalyzes methylene tetrahydrofolate (MTHF)/dUMP conversion to dihydrofolate/dTMP in thymidine triphosphate/deoxyribonucleotide biosynthesis. Thymidylate synthetase competes with the methylene tetrahydrofolate receptor for MTHF and maintains the dTMP pool for DNA replication and repair.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Thymidylate synthetase protein (312 aa, ~36 kDa) is encoded by the human TYMS gene. The protein is a conserved transferase enzyme that catalyzes methylene tetrahydrofolate (MTHF)/dUMP conversion to dihydrofolate/dTMP in thymidine triphosphate/deoxyribonucleotide biosynthesis. Thymidylate synthetase competes with the methylene tetrahydrofolate receptor for MTHF and maintains the dTMP pool for DNA replication and repair. |
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| prefLabel | Thymidylate Synthase
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| label | Thymidylate Synthase
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| code | C17199
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| prefixIRI | NCIT:C17199
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| OMIM_Number | 188350
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| in_subset | |
| Display_Name | Thymidylate Synthase
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| Preferred_Name | Thymidylate Synthase
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| Contributing_Source | CTRP
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| Swiss_Prot | P04818
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| Legacy Concept Name | Thymidylate_Synthase
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| type | |
| ALT_DEFINITION | A protein involved in making and repairing DNA (molecules inside cells that carry genetic information and pass it on from parent to child). High levels of thymidylate synthase may be involved in how certain types of cancer form and respond to treatment.
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| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Enzyme
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| UMLS_CUI | C4043049
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