Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Flortaucipir F-18
Synonyms
Definitions

A radioconjugate composed of the paired helical filament (PHF) tau binding agent flortaucipir, a benzimidazole pyrimidine derivative, conjugated to the radioisotope fluorine F 18, with potential tau positron emission tomography (PET) imaging activity. Upon administration, flortaucipir F-18 targets and binds to PHF-tau in the brain, which allows PET imaging of PHF-tau and analysis of phosphorylated PHF-tau aggregates (neurofibrillary tangles). Increased levels of PHF-tau and neurofibrillary tangles are correlated with the cognitive decline seen in neurodegenerative diseases, such as dementia, Alzheimer's disease (AD) and chemotherapy-induced cognitive impairment (CICI).
ID

http://purl.obolibrary.org/obo/NCIT_C171887
CAS_Registry

1522051-90-6
code

C171887
Contributing_Source

CTRP

FDA
definition

A radioconjugate composed of the paired helical filament (PHF) tau binding agent flortaucipir, a benzimidazole pyrimidine derivative, conjugated to the radioisotope fluorine F 18, with potential tau positron emission tomography (PET) imaging activity. Upon administration, flortaucipir F-18 targets and binds to PHF-tau in the brain, which allows PET imaging of PHF-tau and analysis of phosphorylated PHF-tau aggregates (neurofibrillary tangles). Increased levels of PHF-tau and neurofibrillary tangles are correlated with the cognitive decline seen in neurodegenerative diseases, such as dementia, Alzheimer's disease (AD) and chemotherapy-induced cognitive impairment (CICI).
Display_Name

Flortaucipir F-18
FDA_UNII_Code

T1JP1KYU9O
Has_Target

http://purl.obolibrary.org/obo/NCIT_C75652
in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C176424

http://purl.obolibrary.org/obo/NCIT_C116977

http://purl.obolibrary.org/obo/NCIT_C116978
label

Flortaucipir F-18
NCI_Drug_Dictionary_ID

809198
NCI_META_CUI

CL1406084
Preferred_Name

Flortaucipir F-18
prefixIRI

NCIT:C171887
prefLabel

Flortaucipir F-18
Semantic_Type

Pharmacologic Substance

Indicator, Reagent, or Diagnostic Aid
subClassOf

http://purl.obolibrary.org/obo/NCIT_C2124
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