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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C171629
http://purl.obolibrary.org/obo/NCIT_C171629
|
|---|---|
| Preferred Name | DNA Topoisomerase 1 Cleavable Complex |
| Definitions |
A complex between the enzyme DNA topoisomerase 1 (TOP1) and its DNA substrate. Under normal conditions these complexes are transient and found at low levels. In the presence of therapeutic TOP1 inhibitors these complexes are stabilized, which prevents DNA religation and induces lethal DNA strand breaks.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A complex between the enzyme DNA topoisomerase 1 (TOP1) and its DNA substrate. Under normal conditions these complexes are transient and found at low levels. In the presence of therapeutic TOP1 inhibitors these complexes are stabilized, which prevents DNA religation and induces lethal DNA strand breaks. |
|---|---|
| prefLabel | DNA Topoisomerase 1 Cleavable Complex
|
| label | DNA Topoisomerase 1 Cleavable Complex
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| NCI_META_CUI | CL1405856
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| code | C171629
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| prefixIRI | NCIT:C171629
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| in_subset | |
| Display_Name | DNA Topoisomerase 1 Cleavable Complex
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| Preferred_Name | DNA Topoisomerase 1 Cleavable Complex
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| Contributing_Source | CTRP
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| type | |
| subClassOf | |
| Semantic_Type | Amino Acid, Peptide, or Protein
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