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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C171616
http://purl.obolibrary.org/obo/NCIT_C171616
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|---|---|
| Preferred Name | MDM2 Inhibitor AMGMDS3 |
| Definitions |
An inhibitor of MDM2 (murine double minute 2), with potential antineoplastic activity. Upon administration, MDM2 inhibitor AMGMDS3 binds to the MDM2 protein and prevents its binding to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the transcriptional activity of p53 is restored. This leads to p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger protein and a negative regulator of the p53 pathway, is overexpressed in cancer cells; it plays a key role in cancer cell proliferation and survival.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An inhibitor of MDM2 (murine double minute 2), with potential antineoplastic activity. Upon administration, MDM2 inhibitor AMGMDS3 binds to the MDM2 protein and prevents its binding to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the transcriptional activity of p53 is restored. This leads to p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger protein and a negative regulator of the p53 pathway, is overexpressed in cancer cells; it plays a key role in cancer cell proliferation and survival. |
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| prefLabel | MDM2 Inhibitor AMGMDS3
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| label | MDM2 Inhibitor AMGMDS3
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| NCI_META_CUI | CL1405838
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| code | C171616
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| prefixIRI | NCIT:C171616
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| in_subset | |
| Preferred_Name | MDM2 Inhibitor AMGMDS3
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| Maps_To | MDM2 Inhibitor AMGMDS3
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type | Pharmacologic Substance
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