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Biological and Environmental Research Ontology
| Id | http://purl.obolibrary.org/obo/NCIT_C170976
http://purl.obolibrary.org/obo/NCIT_C170976
|
|---|---|
| Preferred Name | Anti-PRAME T-cell Receptor/Anti-CD3 scFv Fusion Protein IMC-F106C |
| Definitions |
A T-cell re-directing bi-specific biologic composed of a modified form of human T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) preferentially expressed antigen in melanoma (PRAME) and fused to an anti-CD3 single-chain variable fragment (scFv), with potential antineoplastic activity. Upon administration of IMC-F106C, the TCR moiety of this agent targets and binds to PRAME on tumor cells and the anti-CD3 scFv moiety binds to CD3- expressing T-lymphocytes. This selectively cross-links tumor cells and T-lymphocytes and results in a CTL-mediated death of PRAME-expressing tumor cells. The TAA PRAME is overexpressed by a variety of cancer cell types.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A T-cell re-directing bi-specific biologic composed of a modified form of human T-cell receptor (TCR) specific for the tumor-associated antigen (TAA) preferentially expressed antigen in melanoma (PRAME) and fused to an anti-CD3 single-chain variable fragment (scFv), with potential antineoplastic activity. Upon administration of IMC-F106C, the TCR moiety of this agent targets and binds to PRAME on tumor cells and the anti-CD3 scFv moiety binds to CD3- expressing T-lymphocytes. This selectively cross-links tumor cells and T-lymphocytes and results in a CTL-mediated death of PRAME-expressing tumor cells. The TAA PRAME is overexpressed by a variety of cancer cell types. |
|---|---|
| prefLabel | Anti-PRAME T-cell Receptor/Anti-CD3 scFv Fusion Protein IMC-F106C
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| label | Anti-PRAME T-cell Receptor/Anti-CD3 scFv Fusion Protein IMC-F106C
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| NCI_META_CUI | CL1383231
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| PDQ_Closed_Trial_Search_ID | 801222
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| code | C170976
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| Has_Target | |
| prefixIRI | NCIT:C170976
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| in_subset |
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| Display_Name | Anti-PRAME T-cell Receptor/Anti-CD3 scFv Fusion Protein IMC-F106C
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| Preferred_Name | Anti-PRAME T-cell Receptor/Anti-CD3 scFv Fusion Protein IMC-F106C
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| Contributing_Source | CTRP
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| Maps_To | Anti-PRAME T-cell Receptor/Anti-CD3 scFv Fusion Protein IMC-F106C
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| NCI_Drug_Dictionary_ID | 801222
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 801222
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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