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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C170918
http://purl.obolibrary.org/obo/NCIT_C170918
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|---|---|
| Preferred Name | HIF2a RNAi ARO-HIF2 |
| Definitions |
An RNA interference (RNAi) targeting hypoxia-inducible factor 2alpha (HIF-2a), with potential antineoplastic activity. Upon administration of HIF2a RNAi ARO-HIF2, the agent binds to and neutralizes mRNA HIF2a, thereby preventing the production of HIF2a. This may lead to an inhibition of tumor cell proliferation. HIF2a, overexpressed in certain cell types, plays a key role in proliferation, progression and metastasis of tumors.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An RNA interference (RNAi) targeting hypoxia-inducible factor 2alpha (HIF-2a), with potential antineoplastic activity. Upon administration of HIF2a RNAi ARO-HIF2, the agent binds to and neutralizes mRNA HIF2a, thereby preventing the production of HIF2a. This may lead to an inhibition of tumor cell proliferation. HIF2a, overexpressed in certain cell types, plays a key role in proliferation, progression and metastasis of tumors. |
|---|---|
| prefLabel | HIF2a RNAi ARO-HIF2
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| label | HIF2a RNAi ARO-HIF2
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| NCI_META_CUI | CL1383073
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| PDQ_Closed_Trial_Search_ID | 801198
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| code | C170918
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| Has_Target | |
| prefixIRI | NCIT:C170918
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| in_subset |
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| Display_Name | HIF2a RNAi ARO-HIF2
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| Preferred_Name | HIF2a RNAi ARO-HIF2
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| Contributing_Source | CTRP
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| Maps_To | HIF2a RNAi ARO-HIF2
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| NCI_Drug_Dictionary_ID | 801198
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 801198
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| Semantic_Type | Pharmacologic Substance
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