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Biological and Environmental Research Ontology
| Id | http://purl.obolibrary.org/obo/NCIT_C170915
http://purl.obolibrary.org/obo/NCIT_C170915
|
|---|---|
| Preferred Name | Anti-BCMA Antibody-drug Conjugate CC-99712 |
| Definitions |
An antibody-drug conjugate (ADC) consisting of a monoclonal antibody against the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA, TNFRSF17), linked to an as of yet undisclosed cytotoxic agent, with potential antineoplastic activity. Upon administration of anti-BCMA ADC CC-99712, the antibody moiety targets and binds to the cell surface antigen BCMA expressed on certain cancer cells. Upon binding and internalization, the cytotoxic agent is released and kills the BCMA-expressing cancer cells through an as of yet unknown mechanism of action. BCMA, a receptor for a proliferation-inducing ligand (APRIL; tumor necrosis factor ligand superfamily member 13; TNFSF13), and B-cell activating factor (BAFF), is a member of the tumor necrosis factor (TNF) receptor superfamily and plays a key role in plasma survival. It is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An antibody-drug conjugate (ADC) consisting of a monoclonal antibody against the tumor-associated antigen (TAA) B-cell maturation antigen (BCMA, TNFRSF17), linked to an as of yet undisclosed cytotoxic agent, with potential antineoplastic activity. Upon administration of anti-BCMA ADC CC-99712, the antibody moiety targets and binds to the cell surface antigen BCMA expressed on certain cancer cells. Upon binding and internalization, the cytotoxic agent is released and kills the BCMA-expressing cancer cells through an as of yet unknown mechanism of action. BCMA, a receptor for a proliferation-inducing ligand (APRIL; tumor necrosis factor ligand superfamily member 13; TNFSF13), and B-cell activating factor (BAFF), is a member of the tumor necrosis factor (TNF) receptor superfamily and plays a key role in plasma survival. It is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells. |
|---|---|
| prefLabel | Anti-BCMA Antibody-drug Conjugate CC-99712
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| label | Anti-BCMA Antibody-drug Conjugate CC-99712
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| NCI_META_CUI | CL1383075
|
| PDQ_Closed_Trial_Search_ID | 800869
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| code | C170915
|
| prefixIRI | NCIT:C170915
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| in_subset | |
| Display_Name | Anti-BCMA Antibody-drug Conjugate CC-99712
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| Preferred_Name | Anti-BCMA Antibody-drug Conjugate CC-99712
|
| Contributing_Source | CTRP
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| Maps_To | Anti-BCMA Antibody-drug Conjugate CC-99712
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| NCI_Drug_Dictionary_ID | 800869
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 800869
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| Semantic_Type | Pharmacologic Substance
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