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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C170890
http://purl.obolibrary.org/obo/NCIT_C170890
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|---|---|
| Preferred Name | Interleukin-15/Interleukin-15 Receptor Alpha Complex-Fc Fusion Protein XmAb24306 |
| Definitions |
An interleukin (IL)-15/IL-15-receptor alpha (IL-15Ra) complex fused to a bispecific Fc domain, with potential antineoplastic activity. Upon administration, XmAb24306 stimulates the proliferation of natural killer (NK) cells and memory CD8+ T-cells. The memory T-cells enhance the secretion of the cytokine interferon-gamma (IFN-g), which further potentiates the immune response against tumor cells. This may increase tumor cell killing and decrease tumor cell proliferation. IL-15 regulates CD8+ T and NK cell development, activation and proliferation. XmAb24306 does not require endogenous IL-15Ra for its activation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An interleukin (IL)-15/IL-15-receptor alpha (IL-15Ra) complex fused to a bispecific Fc domain, with potential antineoplastic activity. Upon administration, XmAb24306 stimulates the proliferation of natural killer (NK) cells and memory CD8+ T-cells. The memory T-cells enhance the secretion of the cytokine interferon-gamma (IFN-g), which further potentiates the immune response against tumor cells. This may increase tumor cell killing and decrease tumor cell proliferation. IL-15 regulates CD8+ T and NK cell development, activation and proliferation. XmAb24306 does not require endogenous IL-15Ra for its activation. |
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| prefLabel | Interleukin-15/Interleukin-15 Receptor Alpha Complex-Fc Fusion Protein XmAb24306
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| label | Interleukin-15/Interleukin-15 Receptor Alpha Complex-Fc Fusion Protein XmAb24306
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| NCI_META_CUI | CL1383037
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| PDQ_Closed_Trial_Search_ID | 801195
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| code | C170890
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| prefixIRI | NCIT:C170890
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| in_subset |
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| Display_Name | Interleukin-15/Interleukin-15 Receptor Alpha Complex-Fc Fusion Protein XmAb24306
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| Preferred_Name | Interleukin-15/Interleukin-15 Receptor Alpha Complex-Fc Fusion Protein XmAb24306
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| Contributing_Source | CTRP
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| Maps_To | Interleukin-15/Interleukin-15 Receptor Alpha Complex-Fc Fusion Protein XmAb24306
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| NCI_Drug_Dictionary_ID | 801195
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 801195
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| Semantic_Type | Pharmacologic Substance
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