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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Glucocorticoid Receptor | |
| Synonyms |
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| Definitions |
Glucocorticoid receptor (777 aa, ~86 kDa) is encoded by the human NR3C1 gene. This protein plays a role in both chromatin remodeling and transcriptional regulation. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C17071 |
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| code |
C17071
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| Contributing_Source |
CTRP
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| definition |
Glucocorticoid receptor (777 aa, ~86 kDa) is encoded by the human NR3C1 gene. This protein plays a role in both chromatin remodeling and transcriptional regulation.
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| DesignNote |
Complexed with HSP90, HSP70, and FKBP5 or PPP5C, activated GR is transported (by dynein/FKBP4) to the nucleus and binds to target GREs as a homodimeric or heterodimeric (NR3C2/RXR) transcription factor and modulates other transcription factors to regulate blood glucose concentration, protein/fat metabolism, inflammatory responses, cell proliferation, and differentiation. GR appears to interact with NRIP1, POU2F1, POU2F2, STAT5A, STAT5B, SMARCA4, CREBBP/EP300, TADA2L, p160, NCOA2, and NCOA6. Sumoylation and BAG1 interaction inhibits transactivation.
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| Display_Name |
Glucocorticoid Receptor
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C116977 |
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| label |
Glucocorticoid Receptor
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| Legacy Concept Name |
Glucocorticoid_Receptor
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| OMIM_Number |
138040
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| Preferred_Name |
Glucocorticoid Receptor
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| prefixIRI |
NCIT:C17071
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| prefLabel |
Glucocorticoid Receptor
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| Semantic_Type |
Amino Acid, Peptide, or Protein Receptor
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| Swiss_Prot |
P04150
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| UMLS_CUI |
C0034809
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| subClassOf |
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