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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C17071
http://purl.obolibrary.org/obo/NCIT_C17071
|
|---|---|
| Preferred Name | Glucocorticoid Receptor |
| Definitions |
Glucocorticoid receptor (777 aa, ~86 kDa) is encoded by the human NR3C1 gene. This protein plays a role in both chromatin remodeling and transcriptional regulation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Glucocorticoid receptor (777 aa, ~86 kDa) is encoded by the human NR3C1 gene. This protein plays a role in both chromatin remodeling and transcriptional regulation. |
|---|---|
| prefLabel | Glucocorticoid Receptor
|
| label | Glucocorticoid Receptor
|
| code | C17071
|
| prefixIRI | NCIT:C17071
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| OMIM_Number | 138040
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| in_subset | |
| Display_Name | Glucocorticoid Receptor
|
| Preferred_Name | Glucocorticoid Receptor
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| Contributing_Source | CTRP
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| Swiss_Prot | P04150
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| Legacy Concept Name | Glucocorticoid_Receptor
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| DesignNote | Complexed with HSP90, HSP70, and FKBP5 or PPP5C, activated GR is transported (by dynein/FKBP4) to the nucleus and binds to target GREs as a homodimeric or heterodimeric (NR3C2/RXR) transcription factor and modulates other transcription factors to regulate blood glucose concentration, protein/fat metabolism, inflammatory responses, cell proliferation, and differentiation. GR appears to interact with NRIP1, POU2F1, POU2F2, STAT5A, STAT5B, SMARCA4, CREBBP/EP300, TADA2L, p160, NCOA2, and NCOA6. Sumoylation and BAG1 interaction inhibits transactivation.
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| type | |
| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Receptor
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| UMLS_CUI | C0034809
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