loading...| Preferred Name |
Androgen Receptor |
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| Synonyms |
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| Definitions |
Androgen receptor (919 aa, ~99 kDa) is encoded by the human AR gene. This protein plays a role in the modulation of steroid-dependent gene transcription. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C17063 |
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| code |
C17063 |
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| Contributing_Source |
CTRP |
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| definition |
Androgen receptor (919 aa, ~99 kDa) is encoded by the human AR gene. This protein plays a role in the modulation of steroid-dependent gene transcription. |
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| DesignNote |
AR has 3 domains: N-terminal modulating (exon 1), DNA-binding (two C4 Zinc fingers, exons 2-3), and C-terminal hormone-binding (5 remaining exons). Polymorphic N-terminal poly-Gln tracts bind RAN, enhancing transactivation; decreased with increased poly-Gln length. An 87-kD (AR-A) isoform lacks a normal N-terminus, seen in the 110 kD (AR-B) form; A and B may differ in function. Ligand bound receptor translocates to the nucleus, homodimerizes, binds DNA, and stimulates transcription. |
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| Display_Name |
Androgen Receptor |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C116977 |
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| label |
Androgen Receptor |
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| Legacy Concept Name |
Androgen_Receptor |
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| OMIM_Number |
313700 |
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| Preferred_Name |
Androgen Receptor |
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| prefixIRI |
NCIT:C17063 |
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| prefLabel |
Androgen Receptor |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Receptor |
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| Swiss_Prot |
P10275 |
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| UMLS_CUI |
C0034786 |
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| subClassOf |