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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1706
http://purl.obolibrary.org/obo/NCIT_C1706
|
|---|---|
| Preferred Name | Sabarubicin |
| Definitions |
A disaccharide analogue of the anthracycline antineoplastic antibiotic doxorubicin. Sabarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also induces apoptosis through a p53-independent mechanism. Sabarubicin is less cardiotoxic than doxorubicin.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A disaccharide analogue of the anthracycline antineoplastic antibiotic doxorubicin. Sabarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also induces apoptosis through a p53-independent mechanism. Sabarubicin is less cardiotoxic than doxorubicin. |
|---|---|
| prefLabel | Sabarubicin
|
| label | Sabarubicin
|
| PDQ_Closed_Trial_Search_ID | 42684
|
| code | C1706
|
| prefixIRI | NCIT:C1706
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| in_subset | |
| Preferred_Name | Sabarubicin
|
| FDA_UNII_Code | XS499WOZ93
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| Contributing_Source | FDA
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| Chemical_Formula | C32H37NO13
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| Maps_To | Sabarubicin
|
| CAS_Registry | 211100-13-9
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| NCI_Drug_Dictionary_ID | 42684
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| Legacy Concept Name | MEN-10755
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| type | |
| ALT_DEFINITION | An anticancer drug that belongs to the family of drugs called antitumor antibiotics.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42684
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
Antibiotic
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| UMLS_CUI | C0664590
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