Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C1704
http://purl.obolibrary.org/obo/NCIT_C1704
Preferred Name

Nelarabine
Definitions
An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells. (NCI04)
prefLabel
Nelarabine
label
Nelarabine
CHEBI_ID
CHEBI:63612
PDQ_Closed_Trial_Search_ID
43260
code
C1704
Has_Target
prefixIRI
NCIT:C1704
in_subset
Display_Name
Nelarabine
Preferred_Name
Nelarabine
FDA_UNII_Code
60158CV180
Contributing_Source
CTRP
FDA
Chemical_Formula
C11H15N5O5
Maps_To
Nelarabine
CAS_Registry
121032-29-9
NSC Number
686673
NCI_Drug_Dictionary_ID
43260
Legacy Concept Name
Nelarabine
type
ALT_DEFINITION
A drug used to treat certain types of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). It belongs to the family of drugs called antimetabolites.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
43260
Accepted_Therapeutic_Use_For
T-cell Acute Lymphoblastic Leukemia; T-cell Lymphoblastic Lymphoma
Semantic_Type
Pharmacologic Substance
Nucleic Acid, Nucleoside, or Nucleotide
UMLS_CUI
C0907349
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