Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C1703
http://purl.obolibrary.org/obo/NCIT_C1703
Preferred Name

Tipifarnib
Definitions
A nonpeptidomimetic quinolinone with potential antineoplastic activity. Tipifarnib binds to and inhibits the enzyme farnesyl protein transferase, an enzyme involved in protein processing (farnesylation) for signal transduction. By inhibiting the farnesylation of proteins, this agent prevents the activation of Ras oncogenes, inhibits cell growth, induces apoptosis, and inhibits angiogenesis. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A nonpeptidomimetic quinolinone with potential antineoplastic activity. Tipifarnib binds to and inhibits the enzyme farnesyl protein transferase, an enzyme involved in protein processing (farnesylation) for signal transduction. By inhibiting the farnesylation of proteins, this agent prevents the activation of Ras oncogenes, inhibits cell growth, induces apoptosis, and inhibits angiogenesis. (NCI04)
prefLabel
Tipifarnib
label
Tipifarnib
PDQ_Closed_Trial_Search_ID
42626
code
C1703
Has_Target
prefixIRI
NCIT:C1703
in_subset
Display_Name
Tipifarnib
Preferred_Name
Tipifarnib
FDA_UNII_Code
MAT637500A
Contributing_Source
CTRP
FDA
Chemical_Formula
C27H22Cl2N4O
Maps_To
Tipifarnib
CAS_Registry
192185-72-1
NSC Number
702818
NCI_Drug_Dictionary_ID
42626
Legacy Concept Name
Tipifarnib
type
ALT_DEFINITION
A substance that is being studied in the treatment of acute myeloid leukemia (AML) and other types of cancer. It belongs to the family of drugs called farnesyltransferase inhibitors.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
42626
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C1176289
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