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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C17017
http://purl.obolibrary.org/obo/NCIT_C17017
|
|---|---|
| Preferred Name | Protein Kinase C |
| Definitions |
A family of serine/threonine protein kinases that have a structurally conserved catalytic subunit and a regulatory subunit that are connected by a hinge domain.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A family of serine/threonine protein kinases that have a structurally conserved catalytic subunit and a regulatory subunit that are connected by a hinge domain. |
|---|---|
| prefLabel | Protein Kinase C
|
| label | Protein Kinase C
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| code | C17017
|
| prefixIRI | NCIT:C17017
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| in_subset | |
| Display_Name | Protein Kinase C
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| Preferred_Name | Protein Kinase C
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| Contributing_Source | CTRP
|
| Legacy Concept Name | Protein_Kinase-C
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| DesignNote | There are 3 classes of protein kinase C isozymes based on the molecular requirement for activation. Conventional isozymes need calcium ions, diacylglycerol and phospholipids for activation. Novel isozymes require diacylglycerol and are not regulated by calcium ions, while atypical isozymes require neither diacylglycerol nor calcium ions.
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| type | |
| ALT_DEFINITION | An enzyme found throughout the body's tissues and organs. Several forms of PKC are involved in many cellular functions. PKC is being studied in the treatment of cancer.
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| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Enzyme
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| UMLS_CUI | C0033634
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