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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C169053
http://purl.obolibrary.org/obo/NCIT_C169053
|
|---|---|
| Preferred Name | Anti-PSMA/CD3 Bispecific Antibody CCW702 |
| Definitions |
A bispecific antibody that targets both the tumor-associated antigen (TAA) human prostate-specific membrane antigen (PSMA) and the CD3 antigen found on T-lymphocytes, with potential immunostimulatory and antineoplastic activities. Upon administration of anti-PSMA/CD3 bispecific antibody CCW702, this bispecific antibody binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and PSMA found on PSMA-expressing tumor cells. This activates and redirects CTLs to PSMA-expressing tumor cells, which results in the CTL-mediated cell death of PSMA-expressing tumor cells. PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate cancer cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A bispecific antibody that targets both the tumor-associated antigen (TAA) human prostate-specific membrane antigen (PSMA) and the CD3 antigen found on T-lymphocytes, with potential immunostimulatory and antineoplastic activities. Upon administration of anti-PSMA/CD3 bispecific antibody CCW702, this bispecific antibody binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and PSMA found on PSMA-expressing tumor cells. This activates and redirects CTLs to PSMA-expressing tumor cells, which results in the CTL-mediated cell death of PSMA-expressing tumor cells. PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate cancer cells. |
|---|---|
| prefLabel | Anti-PSMA/CD3 Bispecific Antibody CCW702
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| label | Anti-PSMA/CD3 Bispecific Antibody CCW702
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| NCI_META_CUI | CL1378858
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| PDQ_Closed_Trial_Search_ID | 800617
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| code | C169053
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| Has_Target | |
| prefixIRI | NCIT:C169053
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| in_subset |
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| Display_Name | Anti-PSMA/CD3 Bispecific Antibody CCW702
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| Preferred_Name | Anti-PSMA/CD3 Bispecific Antibody CCW702
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| Contributing_Source | CTRP
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| Maps_To | Anti-PSMA/CD3 Bispecific Antibody CCW702
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| NCI_Drug_Dictionary_ID | 800617
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 800617
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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