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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C168996
http://purl.obolibrary.org/obo/NCIT_C168996
|
|---|---|
| Preferred Name | Thorium Th 227 Anti-HER2 Monoclonal Antibody BAY2701439 |
| Definitions |
A radioimmunoconjugate consisting of a monoclonal antibody targeting the tyrosine kinase receptor epidermal growth factor receptor 2 (HER2; ErbB2) and labeled with the alpha-emitting radioisotope thorium Th 227, with potential antineoplastic activity. Upon administration, the monoclonal antibody moiety of BAY2701439 targets and specifically binds to HER2 on tumor cells, delivering a cytotoxic dose of alpha radiation to cells expressing HER2. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A radioimmunoconjugate consisting of a monoclonal antibody targeting the tyrosine kinase receptor epidermal growth factor receptor 2 (HER2; ErbB2) and labeled with the alpha-emitting radioisotope thorium Th 227, with potential antineoplastic activity. Upon administration, the monoclonal antibody moiety of BAY2701439 targets and specifically binds to HER2 on tumor cells, delivering a cytotoxic dose of alpha radiation to cells expressing HER2. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation. |
|---|---|
| label | Thorium Th 227 Anti-HER2 Monoclonal Antibody BAY2701439
|
| prefLabel | Thorium Th 227 Anti-HER2 Monoclonal Antibody BAY2701439
|
| in_subset |
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| Preferred_Name | Thorium Th 227 Anti-HER2 Monoclonal Antibody BAY2701439
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| Is_Value_For_GDC_Property | |
| Display_Name | Thorium Th 227 Anti-HER2 Monoclonal Antibody BAY2701439
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| Maps_To | Thorium Th 227 Anti-HER2 Monoclonal Antibody BAY2701439
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| PDQ_Open_Trial_Search_ID | 800871
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| Has_Target | |
| prefixIRI | NCIT:C168996
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| NCI_Drug_Dictionary_ID | 800871
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| Contributing_Source | CTRP
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| subClassOf | |
| code | C168996
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| type | |
| PDQ_Closed_Trial_Search_ID | 800871
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| NCI_META_CUI | CL1378806
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