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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1689
http://purl.obolibrary.org/obo/NCIT_C1689
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|---|---|
| Preferred Name | Plitidepsin |
| Definitions |
A cyclic depsipeptide isolated from the marine tunicate Aplidium albicans. Plitidepsin displays a broad spectrum of antitumor activities, inducing apoptosis by triggering mitochondrial cytochrome c release, initiating the Fas/DC95, JNK pathway and activating caspase 3 activation. This agent also inhibits elongation factor 1-a, thereby interfering with protein synthesis, and induces G1 arrest and G2 blockade, thereby inhibiting tumor cell growth.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A cyclic depsipeptide isolated from the marine tunicate Aplidium albicans. Plitidepsin displays a broad spectrum of antitumor activities, inducing apoptosis by triggering mitochondrial cytochrome c release, initiating the Fas/DC95, JNK pathway and activating caspase 3 activation. This agent also inhibits elongation factor 1-a, thereby interfering with protein synthesis, and induces G1 arrest and G2 blockade, thereby inhibiting tumor cell growth. |
|---|---|
| prefLabel | Plitidepsin
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| label | Plitidepsin
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| PDQ_Closed_Trial_Search_ID | 460052
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| code | C1689
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| prefixIRI | NCIT:C1689
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| in_subset |
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| Display_Name | Plitidepsin
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| Preferred_Name | Plitidepsin
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| FDA_UNII_Code | Y76ID234HW
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Plitidepsin
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| CAS_Registry | 137219-37-5
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| NSC Number | 638719
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| NCI_Drug_Dictionary_ID | 460052
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| Legacy Concept Name | Aplidine
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| type | |
| ALT_DEFINITION | A substance that is being studied in the treatment of cancer. It is obtained from a marine organism.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 460052
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C0388638
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