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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1685
http://purl.obolibrary.org/obo/NCIT_C1685
|
|---|---|
| Preferred Name | Dulanermin |
| Definitions |
A recombinant human soluble protein corresponding to amino acids 114-281 of the Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand (RhApo2L/TRAIL) with potential antineoplastic activity. Dulanermin binds to and activates TRAIL receptors 1 and 2 (TRAIL-R1/R2), which may activate caspases and induce p53-independent apoptosis in TRAIL-R1/R2-expressing tumor cells. The pro-apoptotic cell surface receptors TRAIL-R1 and -R2, also known as DR4 (death receptor 4) and DR5 (death receptor 5), are members of the TNF receptor family and are overexpressed by a variety of cancer cell types.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A recombinant human soluble protein corresponding to amino acids 114-281 of the Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand (RhApo2L/TRAIL) with potential antineoplastic activity. Dulanermin binds to and activates TRAIL receptors 1 and 2 (TRAIL-R1/R2), which may activate caspases and induce p53-independent apoptosis in TRAIL-R1/R2-expressing tumor cells. The pro-apoptotic cell surface receptors TRAIL-R1 and -R2, also known as DR4 (death receptor 4) and DR5 (death receptor 5), are members of the TNF receptor family and are overexpressed by a variety of cancer cell types. |
|---|---|
| prefLabel | Dulanermin
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| label | Dulanermin
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| PDQ_Closed_Trial_Search_ID | 564398
|
| code | C1685
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| Has_Target | |
| prefixIRI | NCIT:C1685
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| in_subset |
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| Display_Name | Dulanermin
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| Preferred_Name | Dulanermin
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| FDA_UNII_Code | L65E7T81M5
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C871H1329N243O260S4
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| Maps_To | Dulanermin
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| CAS_Registry | 867153-61-5
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| NCI_Drug_Dictionary_ID | 564398
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| Legacy Concept Name | Therapeutic_TNF-Related_Apoptosis-Inducing_Ligand
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 564398
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| Accepted_Therapeutic_Use_For | metastatic non-small cell lung cancer
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| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| UMLS_CUI | C0385242
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