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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C16836
http://purl.obolibrary.org/obo/NCIT_C16836
|
|---|---|
| Preferred Name | Neprilysin |
| Definitions |
Neprilysin (750 aa, ~86 kDa) is encoded by the human MME gene. This protein is involved in the metabolism of biologically active peptides.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Neprilysin (750 aa, ~86 kDa) is encoded by the human MME gene. This protein is involved in the metabolism of biologically active peptides. |
|---|---|
| prefLabel | Neprilysin
|
| label | Neprilysin
|
| code | C16836
|
| prefixIRI | NCIT:C16836
|
| OMIM_Number | 120520
|
| in_subset | |
| Display_Name | Neprilysin
|
| Preferred_Name | Neprilysin
|
| Contributing_Source |
CTRP
GDC
|
| Swiss_Prot | P08473
|
| Maps_To | CD10
|
| Legacy Concept Name | Membrane_Metalloendopeptidase
|
| DesignNote | Membrane Metalloendopeptidase is a zinc-binding type II transmembrane glycoprotein that preferentially cleaves Gly-Phe bonds of peptides at the N side of hydrophobic residues and inactivates several peptide hormones, including insulin, glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin, as well as casein, hemoglobin, and other proteins and polypeptides. An important cell surface marker of human acute lymphocytic leukemia, MME is present on pre-B leukemic cells, which represent 85% of cases of ALL.
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Enzyme
|
| UMLS_CUI | C0025250
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| Delete | Subject | Author | Type | Created |
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| No notes to display |