Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C1679
http://purl.obolibrary.org/obo/NCIT_C1679
Preferred Name

Exatecan Mesylate
Definitions
A semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater potency than camptothecin and other camptothecin analogues. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater potency than camptothecin and other camptothecin analogues. (NCI04)
prefLabel
Exatecan Mesylate
label
Exatecan Mesylate
PDQ_Closed_Trial_Search_ID
43386
code
C1679
prefixIRI
NCIT:C1679
in_subset
Preferred_Name
Exatecan Mesylate
FDA_UNII_Code
D2VJ1CC26Q
Contributing_Source
FDA
Chemical_Formula
C24H22FN3O4.CH4O3S.2H2O
Maps_To
Exatecan Mesylate
CAS_Registry
197720-53-9
NCI_Drug_Dictionary_ID
43386
Legacy Concept Name
Exatecan_Mesylate
Has_Free_Acid_Or_Base_Form
type
ALT_DEFINITION
An anticancer drug that is a type of topoisomerase inhibitor.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
43386
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0935945
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