Biological and Environmental Research Ontology

Last uploaded: December 23, 2022

Id	http://purl.obolibrary.org/obo/NCIT_C167267 http://purl.obolibrary.org/obo/NCIT_C167267
Preferred Name	SERD ZN-c5
Definitions	An orally available selective estrogen receptor degrader/downregulator (SERD), with potential antineoplastic activity. Upon oral administration, SERD ZN-c5 specifically targets and binds to the estrogen receptor (ER) and induces a conformational change that results in ER degradation. This prevents ER-mediated signaling and inhibits both the growth and survival of ER-expressing cancer cells.
Type	http://www.w3.org/2002/07/owl#Class

definition	An orally available selective estrogen receptor degrader/downregulator (SERD), with potential antineoplastic activity. Upon oral administration, SERD ZN-c5 specifically targets and binds to the estrogen receptor (ER) and induces a conformational change that results in ER degradation. This prevents ER-mediated signaling and inhibits both the growth and survival of ER-expressing cancer cells.
prefLabel	SERD ZN-c5
label	SERD ZN-c5
NCI_META_CUI	CL972255
PDQ_Closed_Trial_Search_ID	802322
code	C167267
Has_Target	http://purl.obolibrary.org/obo/NCIT_C38361
prefixIRI	NCIT:C167267
in_subset	http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C157711 http://purl.obolibrary.org/obo/NCIT_C157712 See more See less
Display_Name	SERD ZN-c5
Preferred_Name	SERD ZN-c5
Contributing_Source	CTRP
Maps_To	SERD ZN-c5
NCI_Drug_Dictionary_ID	802322
type	http://www.w3.org/2002/07/owl#Class
Is_Value_For_GDC_Property	http://purl.obolibrary.org/obo/NCIT_C1909
subClassOf	http://purl.obolibrary.org/obo/NCIT_C2116
PDQ_Open_Trial_Search_ID	802322
Semantic_Type	Pharmacologic Substance

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