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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Ibandronate Sodium | |
| Synonyms |
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| Definitions |
The sodium salt form of ibandronic acid, a synthetic nitrogen-containing bisphosphonate. Ibandronic acid inhibits farnesyl pyrophosphate synthase, resulting in a reduction in geranylgeranyl GTPase signaling proteins and apoptosis of osteoclasts. This agent increases bone mineral density, decreases bone remodeling, inhibits osteoclast-mediated bone resorption, and reduces metastases-related and corticosteroid-related bone pain. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C1670 |
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| Accepted_Therapeutic_Use_For |
Osteoporosis, treatment and prevention
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| ALT_DEFINITION |
A drug that is used to prevent and treat osteoporosis, and is being studied in the treatment of cancer that has spread to the bones. It belongs to the family of drugs called bisphosphonates.
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| CAS_Registry |
138926-19-9
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| Chemical_Formula |
C9H22NO7P2.Na.H2O
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|
| code |
C1670
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| Contributing_Source |
CTRP FDA
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| definition |
The sodium salt form of ibandronic acid, a synthetic nitrogen-containing bisphosphonate. Ibandronic acid inhibits farnesyl pyrophosphate synthase, resulting in a reduction in geranylgeranyl GTPase signaling proteins and apoptosis of osteoclasts. This agent increases bone mineral density, decreases bone remodeling, inhibits osteoclast-mediated bone resorption, and reduces metastases-related and corticosteroid-related bone pain.
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| Display_Name |
Ibandronate Sodium
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|
| FDA_UNII_Code |
J12U072QL0
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Ibandronate Sodium
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|
| Legacy Concept Name |
Ibandronate
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| Maps_To |
Ibandronate Sodium
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|
| NCI_Drug_Dictionary_ID |
365963
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| PDQ_Closed_Trial_Search_ID |
365963
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|
| PDQ_Open_Trial_Search_ID |
365963
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|
| Preferred_Name |
Ibandronate Sodium
|
|
| prefixIRI |
NCIT:C1670
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|
| prefLabel |
Ibandronate Sodium
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0772244
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| subClassOf |
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