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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C16691
http://purl.obolibrary.org/obo/NCIT_C16691
|
|---|---|
| Preferred Name | HLA Class I Histocompatibility Antigen, A-2 Alpha Chain |
| Definitions |
HLA class I histocompatibility antigen, A-2 alpha chain (365 aa, ~41 kDa) is encoded by the human HLA-A gene. This protein is involved in antigen presentation.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | HLA class I histocompatibility antigen, A-2 alpha chain (365 aa, ~41 kDa) is encoded by the human HLA-A gene. This protein is involved in antigen presentation. |
|---|---|
| prefLabel | HLA Class I Histocompatibility Antigen, A-2 Alpha Chain
|
| label | HLA Class I Histocompatibility Antigen, A-2 Alpha Chain
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| code | C16691
|
| prefixIRI | NCIT:C16691
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| OMIM_Number | 142800
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| in_subset | |
| Display_Name | HLA Class I Histocompatibility Antigen, A-2 Alpha Chain
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| Preferred_Name | HLA Class I Histocompatibility Antigen, A-2 Alpha Chain
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| Contributing_Source | CTRP
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| Swiss_Prot | P04439
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| Legacy Concept Name | HLA-A2_Antigen
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| DesignNote | HLA-A protein organization includes a signal peptide, extracellular alpha1, 2, and 3 domains (90-aa each), a transmembrane region, and a cytoplasmic tail. Polymorphic alpha1 and 2 domains determine peptide binding specificity. Ig-like alpha3 mediates CD8 binding on cytotoxic T-lymphocytes. In the immune response, HLA antigens mediate antigen presentation to TCR. HLA-A2 subtypes are associated with decreased risk of HIV-1 infection and increased frequency of early-onset Alzheimer disease. (from LocusLink, Swiss-Prot, OMIM)
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| type | |
| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Immunologic Factor
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| UMLS_CUI | C0019733
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| Delete | Subject | Author | Type | Created |
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