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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C16682
http://purl.obolibrary.org/obo/NCIT_C16682
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|---|---|
| Preferred Name | Histone Deacetylase |
| Definitions |
Histone acetylation and deacetylation alternately exposes and occludes DNA to transcription factors. Histone deacetylation is catalyzed by the histone deacetylases. There are at least 2 classes of HDACs, class I consisting of proteins homologous to yeast Rpd3 (e.g., HDAC1, HDAC2, and HDAC3) and class II consisting of proteins homologous to yeast Hda1 (e.g., HDAC4 and HDAC6). (from OMIM)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | Histone acetylation and deacetylation alternately exposes and occludes DNA to transcription factors. Histone deacetylation is catalyzed by the histone deacetylases. There are at least 2 classes of HDACs, class I consisting of proteins homologous to yeast Rpd3 (e.g., HDAC1, HDAC2, and HDAC3) and class II consisting of proteins homologous to yeast Hda1 (e.g., HDAC4 and HDAC6). (from OMIM) |
|---|---|
| prefLabel | Histone Deacetylase
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| label | Histone Deacetylase
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| code | C16682
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| prefixIRI | NCIT:C16682
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| in_subset | |
| Display_Name | Histone Deacetylase
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| Preferred_Name | Histone Deacetylase
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| Contributing_Source | CTRP
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| Legacy Concept Name | Histone_Deacetylase
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| type | |
| ALT_DEFINITION | An enzyme that removes a small molecule called an acetyl group from histones (proteins found in chromosomes). This changes the way the histones bind to DNA and may affect its activity. HDAC inhibitors are being studied in the treatment of cancer.
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| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Enzyme
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| UMLS_CUI | C0019643
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