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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C166377
http://purl.obolibrary.org/obo/NCIT_C166377
|
|---|---|
| Preferred Name | Synthetic Plumbagin PCUR-101 |
| Definitions |
A synthetic form of the plant-derived medicinal agent, plumbagin, with potential antineoplastic activity. Plumbagin may act by inhibiting the expression of protein kinase C epsilon (PKCe), signal transducers and activators of transcription 3 phosphorylation (Stat3), protein kinase B (AKT), and certain epithelial-to-mesenchymal transition (EMT) markers, including vimentin and slug. This results in possible inhibition of proliferation in susceptible tumor cells. PKCe, Stat3, AKT, and the EMT markers vimentin and slug have been linked to the induction and progression of prostate cancer.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A synthetic form of the plant-derived medicinal agent, plumbagin, with potential antineoplastic activity. Plumbagin may act by inhibiting the expression of protein kinase C epsilon (PKCe), signal transducers and activators of transcription 3 phosphorylation (Stat3), protein kinase B (AKT), and certain epithelial-to-mesenchymal transition (EMT) markers, including vimentin and slug. This results in possible inhibition of proliferation in susceptible tumor cells. PKCe, Stat3, AKT, and the EMT markers vimentin and slug have been linked to the induction and progression of prostate cancer. |
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| label | Synthetic Plumbagin PCUR-101
|
| prefLabel | Synthetic Plumbagin PCUR-101
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| in_subset |
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| Preferred_Name | Synthetic Plumbagin PCUR-101
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| Is_Value_For_GDC_Property | |
| Display_Name | Synthetic Plumbagin PCUR-101
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| Maps_To | Synthetic Plumbagin PCUR-101
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| PDQ_Open_Trial_Search_ID | 792711
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| Has_Target | |
| FDA_UNII_Code | YAS4TBQ4OQ
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| prefixIRI | NCIT:C166377
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| NCI_Drug_Dictionary_ID | 792711
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| Contributing_Source |
CTRP
FDA
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| subClassOf | |
| code | C166377
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| type | |
| PDQ_Closed_Trial_Search_ID | 792711
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| Semantic_Type | Pharmacologic Substance
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| CAS_Registry | 481-42-5
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| NCI_META_CUI | CL971629
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