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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1658
http://purl.obolibrary.org/obo/NCIT_C1658
|
|---|---|
| Preferred Name | Warfarin Sodium |
| Definitions |
The sodium salt form of warfarin, a coumarin and a vitamin K antagonist, with anticoagulant activity. Warfarin sodium inhibits both vitamin K and vitamin K epoxide reductases, thereby interfering with the cyclic interconversion of vitamin K epoxide to its reduced form, vitamin KH2. Vitamin KH2 is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins. As a result, maturation of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Without these coagulation factors, thrombogenesis and blood clot formation are prevented.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The sodium salt form of warfarin, a coumarin and a vitamin K antagonist, with anticoagulant activity. Warfarin sodium inhibits both vitamin K and vitamin K epoxide reductases, thereby interfering with the cyclic interconversion of vitamin K epoxide to its reduced form, vitamin KH2. Vitamin KH2 is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins. As a result, maturation of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Without these coagulation factors, thrombogenesis and blood clot formation are prevented. |
|---|---|
| prefLabel | Warfarin Sodium
|
| label | Warfarin Sodium
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| CHEBI_ID | CHEBI:10034
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| PDQ_Closed_Trial_Search_ID | 39740
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| code | C1658
|
| prefixIRI | NCIT:C1658
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| in_subset |
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| Display_Name | Warfarin Sodium
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| Preferred_Name | Warfarin Sodium
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| FDA_UNII_Code | 6153CWM0CL
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| Contributing_Source |
CTRP
FDA
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| Chemical_Formula | C19H15O4.Na
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| Maps_To | Warfarin Sodium
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| CAS_Registry | 129-06-6
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| NCI_Drug_Dictionary_ID | 39740
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| Legacy Concept Name | Warfarin_Sodium
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| Has_Free_Acid_Or_Base_Form | |
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 39740
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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| UMLS_CUI | C0376218
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