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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C165558
http://purl.obolibrary.org/obo/NCIT_C165558
|
|---|---|
| Preferred Name | Samarium Sm 153-DOTMP |
| Definitions |
A radioconjugate composed of the phosphonic acid chelator DOTMP (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylenephosphonic acid) conjugated to the beta- and gamma-emitting radioisotope samarium Sm 153, with potential antineoplastic activity. Upon administration of samarium Sm 153-DOTMP, the DOTMP moiety targets and binds to growing bone, thereby selectively delivering samarium Sm 153-mediated cytotoxic radiation to bone tumor and metastases, which may help destroy bone metastases and mitigate pain from bone metastases.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A radioconjugate composed of the phosphonic acid chelator DOTMP (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylenephosphonic acid) conjugated to the beta- and gamma-emitting radioisotope samarium Sm 153, with potential antineoplastic activity. Upon administration of samarium Sm 153-DOTMP, the DOTMP moiety targets and binds to growing bone, thereby selectively delivering samarium Sm 153-mediated cytotoxic radiation to bone tumor and metastases, which may help destroy bone metastases and mitigate pain from bone metastases. |
|---|---|
| prefLabel | Samarium Sm 153-DOTMP
|
| label | Samarium Sm 153-DOTMP
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| NCI_META_CUI | CL978665
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| PDQ_Closed_Trial_Search_ID | 799673
|
| code | C165558
|
| prefixIRI | NCIT:C165558
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| in_subset |
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| Display_Name | Samarium Sm 153-DOTMP
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| Preferred_Name | Samarium Sm 153-DOTMP
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| FDA_UNII_Code | S5NN2E9ZKF
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Samarium Sm 153-DOTMP
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| CAS_Registry | 633308-21-1
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| NCI_Drug_Dictionary_ID | 799673
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 799673
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
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