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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C165555
http://purl.obolibrary.org/obo/NCIT_C165555
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|---|---|
| Preferred Name | Alvocidib Prodrug TP-1287 |
| Definitions |
An orally bioavailable, highly soluble phosphate prodrug of alvocidib, a potent inhibitor of cyclin-dependent kinase-9 (CDK9), with potential antineoplastic activity. Upon administration of the phosphate prodrug TP-1287, the prodrug is enzymatically cleaved at the tumor site and the active moiety alvocidib is released. Alvocidib targets and binds to CDK9, thereby reducing the expression of CDK9 target genes such as the anti-apoptotic protein MCL-1, and inducing G1 cell cycle arrest and apoptosis in CDK9-overexpressing cancer cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable, highly soluble phosphate prodrug of alvocidib, a potent inhibitor of cyclin-dependent kinase-9 (CDK9), with potential antineoplastic activity. Upon administration of the phosphate prodrug TP-1287, the prodrug is enzymatically cleaved at the tumor site and the active moiety alvocidib is released. Alvocidib targets and binds to CDK9, thereby reducing the expression of CDK9 target genes such as the anti-apoptotic protein MCL-1, and inducing G1 cell cycle arrest and apoptosis in CDK9-overexpressing cancer cells. |
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| prefLabel | Alvocidib Prodrug TP-1287
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| label | Alvocidib Prodrug TP-1287
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| NCI_META_CUI | CL978685
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| PDQ_Closed_Trial_Search_ID | 799663
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| code | C165555
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| prefixIRI | NCIT:C165555
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| in_subset |
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| Display_Name | Alvocidib Prodrug TP-1287
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| Preferred_Name | Alvocidib Prodrug TP-1287
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| FDA_UNII_Code | 7MPP85IIJ3
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| Contributing_Source |
CTRP
FDA
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| Maps_To | Alvocidib Prodrug TP-1287
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| CAS_Registry | 2044686-42-0
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| NCI_Drug_Dictionary_ID | 799663
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 799663
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| Semantic_Type | Pharmacologic Substance
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