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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C165550
http://purl.obolibrary.org/obo/NCIT_C165550
|
|---|---|
| Preferred Name | SERD SHR9549 |
| Definitions |
An orally available selective estrogen receptor degrader/downregulator (SERD), with potential antineoplastic activity. Upon oral administration, SERD SHR9549 specifically targets and binds to the estrogen receptor (ER) and induces a conformational change that promotes ER degradation. This prevents ER-mediated signaling and inhibits both the growth and survival of ER-expressing cancer cells.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally available selective estrogen receptor degrader/downregulator (SERD), with potential antineoplastic activity. Upon oral administration, SERD SHR9549 specifically targets and binds to the estrogen receptor (ER) and induces a conformational change that promotes ER degradation. This prevents ER-mediated signaling and inhibits both the growth and survival of ER-expressing cancer cells. |
|---|---|
| prefLabel | SERD SHR9549
|
| label | SERD SHR9549
|
| NCI_META_CUI | CL978680
|
| PDQ_Closed_Trial_Search_ID | 799640
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| code | C165550
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| Has_Target | |
| prefixIRI | NCIT:C165550
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| in_subset | |
| Preferred_Name | SERD SHR9549
|
| Maps_To | SERD SHR9549
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| NCI_Drug_Dictionary_ID | 799640
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 799640
|
| Semantic_Type | Pharmacologic Substance
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