Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C165479
http://purl.obolibrary.org/obo/NCIT_C165479
Preferred Name

Pictilisib
Definitions
A small molecule inhibitor of class I phosphatidylinositol 3 kinase (PI3K), with potential antineoplastic activity. Upon administration, pictilisib selectively binds to PI3K in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway. This may result in inhibition of tumor cell growth, motility and survival in susceptible tumor cell populations. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis; dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A small molecule inhibitor of class I phosphatidylinositol 3 kinase (PI3K), with potential antineoplastic activity. Upon administration, pictilisib selectively binds to PI3K in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway. This may result in inhibition of tumor cell growth, motility and survival in susceptible tumor cell populations. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis; dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.
prefLabel
Pictilisib
label
Pictilisib
NCI_META_CUI
CL978574
code
C165479
prefixIRI
NCIT:C165479
in_subset
Preferred_Name
Pictilisib
FDA_UNII_Code
ICY00EMP8P
Contributing_Source
FDA
Maps_To
Pictilisib
CAS_Registry
957054-30-7
type
Is_Value_For_GDC_Property
subClassOf
Semantic_Type
Pharmacologic Substance
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