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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C165436
http://purl.obolibrary.org/obo/NCIT_C165436
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|---|---|
| Preferred Name | RAD51 Inhibitor CYT-0851 |
| Definitions |
An orally bioavailable inhibitor of the DNA damage repair protein RAD51, with potential antineoplastic and sensitizing activities. Upon oral administration, the RAD51 inhibitor CYT-0851 targets, binds to and inhibits the activity of RAD51. This prevents RAD51-mediated DNA damage repair in susceptible tumor cells and induces tumor cell apoptosis. RAD51, the central protein involved in homologous repair (HR) of DNA double-strand breaks (DSBs), is overexpressed in many tumor cell types.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally bioavailable inhibitor of the DNA damage repair protein RAD51, with potential antineoplastic and sensitizing activities. Upon oral administration, the RAD51 inhibitor CYT-0851 targets, binds to and inhibits the activity of RAD51. This prevents RAD51-mediated DNA damage repair in susceptible tumor cells and induces tumor cell apoptosis. RAD51, the central protein involved in homologous repair (HR) of DNA double-strand breaks (DSBs), is overexpressed in many tumor cell types. |
|---|---|
| prefLabel | RAD51 Inhibitor CYT-0851
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| label | RAD51 Inhibitor CYT-0851
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| NCI_META_CUI | CL978621
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| PDQ_Closed_Trial_Search_ID | 799774
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| code | C165436
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| Has_Target | |
| prefixIRI | NCIT:C165436
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| in_subset |
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| Display_Name | RAD51 Inhibitor CYT-0851
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| Preferred_Name | RAD51 Inhibitor CYT-0851
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| Contributing_Source | CTRP
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| Maps_To | RAD51 Inhibitor CYT-0851
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| NCI_Drug_Dictionary_ID | 799774
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| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 799774
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| Semantic_Type | Pharmacologic Substance
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