Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C165238
http://purl.obolibrary.org/obo/NCIT_C165238
|
|---|---|
| Preferred Name | Aurora A Kinase Inhibitor LY3295668 Erbumine |
| Definitions |
The tert-butylamine salt form of LY3295668, an orally bioavailable inhibitor of the serine/threonine protein kinase aurora A, with potential antimitotic and antineoplastic activities. Upon administration, aurora A kinase inhibitor LY3295668 targets, binds to and inhibits the activity of aurora A kinase. This may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, inhibition of cell division and the induction of apoptosis in cells overexpressing aurora A kinase. Aurora A kinase, overexpressed in a wide variety of cancers, plays an essential role in the regulation of spindle assembly and mitosis.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | The tert-butylamine salt form of LY3295668, an orally bioavailable inhibitor of the serine/threonine protein kinase aurora A, with potential antimitotic and antineoplastic activities. Upon administration, aurora A kinase inhibitor LY3295668 targets, binds to and inhibits the activity of aurora A kinase. This may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, inhibition of cell division and the induction of apoptosis in cells overexpressing aurora A kinase. Aurora A kinase, overexpressed in a wide variety of cancers, plays an essential role in the regulation of spindle assembly and mitosis. |
|---|---|
| prefLabel | Aurora A Kinase Inhibitor LY3295668 Erbumine
|
| label | Aurora A Kinase Inhibitor LY3295668 Erbumine
|
| NCI_META_CUI | CL978388
|
| PDQ_Closed_Trial_Search_ID | 792635
|
| code | C165238
|
| Has_Target | |
| prefixIRI | NCIT:C165238
|
| in_subset | |
| Display_Name | Aurora A Kinase Inhibitor LY3295668 Erbumine
|
| Preferred_Name | Aurora A Kinase Inhibitor LY3295668 Erbumine
|
| Contributing_Source | CTRP
|
| Maps_To | Aurora A Kinase Inhibitor LY3295668 Erbumine
|
| NCI_Drug_Dictionary_ID | 792635
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 792635
|
| Semantic_Type | Pharmacologic Substance
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |