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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C1652
http://purl.obolibrary.org/obo/NCIT_C1652
|
|---|---|
| Preferred Name | Marimastat |
| Definitions |
An orally-active synthetic hydroxamate with potential antineoplastic activity. Marimastat covalently binds to the zinc(II) ion in the active site of matrix metalloproteinases (MMPs), thereby inhibiting the action of MMPs, inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent may also inhibit tumor necrosis factor-alpha converting enzyme (TACE), an enzyme involved in tumor necrosis factor alpha (TNF-alpha) production that may play a role in some malignancies as well as in the development of arthritis and sepsis. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | An orally-active synthetic hydroxamate with potential antineoplastic activity. Marimastat covalently binds to the zinc(II) ion in the active site of matrix metalloproteinases (MMPs), thereby inhibiting the action of MMPs, inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent may also inhibit tumor necrosis factor-alpha converting enzyme (TACE), an enzyme involved in tumor necrosis factor alpha (TNF-alpha) production that may play a role in some malignancies as well as in the development of arthritis and sepsis. (NCI04) |
|---|---|
| prefLabel | Marimastat
|
| label | Marimastat
|
| CHEBI_ID | CHEBI:50662
|
| PDQ_Closed_Trial_Search_ID | 42443
|
| code | C1652
|
| prefixIRI | NCIT:C1652
|
| in_subset | |
| Preferred_Name | Marimastat
|
| FDA_UNII_Code | D5EQV23TDS
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| Contributing_Source | FDA
|
| Chemical_Formula | C15H29N3O5
|
| Maps_To | Marimastat
|
| CAS_Registry | 154039-60-8
|
| NSC Number |
689451
719333
|
| NCI_Drug_Dictionary_ID | 42443
|
| Legacy Concept Name | Marimastat
|
| type | |
| ALT_DEFINITION | An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors. Marimastat is a matrix metalloproteinase inhibitor.
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| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 42443
|
| Semantic_Type |
Organic Chemical
Pharmacologic Substance
|
| UMLS_CUI | C0338344
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