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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C16516
http://purl.obolibrary.org/obo/NCIT_C16516
|
|---|---|
| Preferred Name | DNA Topoisomerase 1 |
| Definitions |
DNA topoisomerase 1 (765 aa, ~91 kDa) is encoded by the human TOP1 gene. This protein plays a role in the regulation of DNA topology.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | DNA topoisomerase 1 (765 aa, ~91 kDa) is encoded by the human TOP1 gene. This protein plays a role in the regulation of DNA topology. |
|---|---|
| prefLabel | DNA Topoisomerase 1
|
| label | DNA Topoisomerase 1
|
| code | C16516
|
| prefixIRI | NCIT:C16516
|
| OMIM_Number | 126420
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| in_subset | |
| Display_Name | Topoisomerase I
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| Preferred_Name | DNA Topoisomerase 1
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| Contributing_Source | CTRP
|
| Swiss_Prot | P11387
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| Legacy Concept Name | Topoisomerase-I
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| DesignNote | DNA topoisomerases I and II relax negative and positive supercoils; TOP1 breaks single DNA strands, TOP2 breaks duplex DNA. Specifically inhibited by the antitumor plant alkaloid CPT, when TOP1 breaks the DNA backbone bond it forms a protein-DNA link (a tyrosyl oxygen joins to a DNA strand end phosphorus).
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| type | |
| subClassOf | |
| Semantic_Type |
Amino Acid, Peptide, or Protein
Enzyme
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| UMLS_CUI | C0012920
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