Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C1651
http://purl.obolibrary.org/obo/NCIT_C1651
Preferred Name

Motexafin Lutetium
Definitions
A pentadentate aromatic metallotexaphyrin with photosensitizing properties. Motexafin lutetium preferentially accumulates in tumor cells due to their increased rates of metabolism and absorbs light, forming an extended high energy conformational state that produces high quantum yields of singlet oxygen, resulting in local cytotoxic effects. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A pentadentate aromatic metallotexaphyrin with photosensitizing properties. Motexafin lutetium preferentially accumulates in tumor cells due to their increased rates of metabolism and absorbs light, forming an extended high energy conformational state that produces high quantum yields of singlet oxygen, resulting in local cytotoxic effects. (NCI04)
prefLabel
Motexafin Lutetium
label
Motexafin Lutetium
PDQ_Closed_Trial_Search_ID
42402
code
C1651
prefixIRI
NCIT:C1651
in_subset
Display_Name
Motexafin Lutetium
Preferred_Name
Motexafin Lutetium
FDA_UNII_Code
0A85BJ22L6
Contributing_Source
CTRP
FDA
Chemical_Formula
C48H66N5O10.2C2H3O2.Lu.H2O
Maps_To
Motexafin Lutetium
CAS_Registry
156436-90-7
246252-04-0
NSC Number
695239
NCI_Drug_Dictionary_ID
42402
Legacy Concept Name
Motexafin_Lutetium
type
ALT_DEFINITION
A substance that is being studied in the treatment of cancer using photodynamic therapy. It belongs to the family of drugs called metallotexaphyrins.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
42402
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0338310
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