Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C163981
http://purl.obolibrary.org/obo/NCIT_C163981
|
|---|---|
| Preferred Name | Pimurutamab |
| Definitions |
A glycoengineered humanized version of the monoclonal antibody of cetuximab, with potential antineoplastic activity. Upon intravenous administration, pimurutamab selectively targets and binds to the extracellular domain of the epidermal growth factor receptor (EGFR), thereby preventing the activation and subsequent dimerization of the receptor. This may prevent EGFR-mediated signaling and inhibit EGFR-dependent tumor cell proliferation. In addition, the glyco-optimization promotes antibody-dependent cell-mediated cytotoxicity (ADCC). EGFR, a member of the epidermal growth factor family of extracellular protein ligands, may be overexpressed on the cell surfaces of certain tumor types.
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A glycoengineered humanized version of the monoclonal antibody of cetuximab, with potential antineoplastic activity. Upon intravenous administration, pimurutamab selectively targets and binds to the extracellular domain of the epidermal growth factor receptor (EGFR), thereby preventing the activation and subsequent dimerization of the receptor. This may prevent EGFR-mediated signaling and inhibit EGFR-dependent tumor cell proliferation. In addition, the glyco-optimization promotes antibody-dependent cell-mediated cytotoxicity (ADCC). EGFR, a member of the epidermal growth factor family of extracellular protein ligands, may be overexpressed on the cell surfaces of certain tumor types. |
|---|---|
| prefLabel | Pimurutamab
|
| label | Pimurutamab
|
| NCI_META_CUI | CL977244
|
| PDQ_Closed_Trial_Search_ID | 799130
|
| code | C163981
|
| Has_Target | |
| prefixIRI | NCIT:C163981
|
| in_subset | |
| Preferred_Name | Pimurutamab
|
| FDA_UNII_Code | 5V1Y8T4RB6
|
| Contributing_Source | FDA
|
| Maps_To |
Pimurutamab
Anti-EGFR Monoclonal Antibody HLX-07
|
| CAS_Registry | 2251771-76-1
|
| NCI_Drug_Dictionary_ID | 799130
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 799130
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
Immunologic Factor
|
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |