Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Id http://purl.obolibrary.org/obo/NCIT_C1635
http://purl.obolibrary.org/obo/NCIT_C1635
Preferred Name

Bexarotene
Definitions
A synthetic retinoic acid agent with potential antineoplastic, chemopreventive, teratogenic and embryotoxic properties. Bexarotene selectively binds to and activates retinoid X receptors (RXRs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, apoptosis of some cancer cell types, and tumor regression. (NCI04)
Type http://www.w3.org/2002/07/owl#Class

All Properties

definition

A synthetic retinoic acid agent with potential antineoplastic, chemopreventive, teratogenic and embryotoxic properties. Bexarotene selectively binds to and activates retinoid X receptors (RXRs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, apoptosis of some cancer cell types, and tumor regression. (NCI04)
prefLabel
Bexarotene
label
Bexarotene
CHEBI_ID
CHEBI:50859
PDQ_Closed_Trial_Search_ID
42117
code
C1635
Has_Target
prefixIRI
NCIT:C1635
in_subset
Display_Name
Bexarotene
Preferred_Name
Bexarotene
FDA_UNII_Code
A61RXM4375
Contributing_Source
CTRP
FDA
Chemical_Formula
C24H28O2
Maps_To
Bexarotene
CAS_Registry
153559-49-0
NCI_Drug_Dictionary_ID
42117
Legacy Concept Name
Bexarotene
type
ALT_DEFINITION
A drug used to treat skin problems caused by cutaneous T-cell lymphoma that have not gotten better after other treatment. It is also being studied in the treatment of other types of cancer. Bexarotene is a type of retinoid.
Is_Value_For_GDC_Property
subClassOf
PDQ_Open_Trial_Search_ID
42117
Accepted_Therapeutic_Use_For
Oral or topical treatment of cutaneous manifestations of cutaneous T-cell lymphoma (CTCL).
Semantic_Type
Organic Chemical
Pharmacologic Substance
UMLS_CUI
C0765273
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