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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C162879
http://purl.obolibrary.org/obo/NCIT_C162879
|
|---|---|
| Preferred Name | Conbercept |
| Definitions |
A recombinant, soluble, vascular endothelial growth factor receptor (VEGFR) protein composed of the second immunoglobulin (Ig) domain of VEGFR-1, the third and fourth Ig domains of VEGFR-2, and the constant region (Fc) of human immunoglobulin G1 (IgG1) with potential anti-angiogenic activities. Upon intravitreal injection, conbercept, functioning as a soluble decoy receptor, binds with high affinity to all VEGF-A isoforms, VEGF-B, as well as placenta growth factor (PlGF)-1 and PlGF-2. This prevents the binding of these growth factors to their endogenous receptors, potentially inhibiting angiogenesis and tumor cell growth.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A recombinant, soluble, vascular endothelial growth factor receptor (VEGFR) protein composed of the second immunoglobulin (Ig) domain of VEGFR-1, the third and fourth Ig domains of VEGFR-2, and the constant region (Fc) of human immunoglobulin G1 (IgG1) with potential anti-angiogenic activities. Upon intravitreal injection, conbercept, functioning as a soluble decoy receptor, binds with high affinity to all VEGF-A isoforms, VEGF-B, as well as placenta growth factor (PlGF)-1 and PlGF-2. This prevents the binding of these growth factors to their endogenous receptors, potentially inhibiting angiogenesis and tumor cell growth. |
|---|---|
| prefLabel | Conbercept
|
| label | Conbercept
|
| NCI_META_CUI | CL973317
|
| PDQ_Closed_Trial_Search_ID | 798956
|
| code | C162879
|
| Has_Target | |
| prefixIRI | NCIT:C162879
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| in_subset | |
| Preferred_Name | Conbercept
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| FDA_UNII_Code | 1P05PW62F3
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| Contributing_Source | FDA
|
| Maps_To | Conbercept
|
| CAS_Registry | 1227158-72-6
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| NCI_Drug_Dictionary_ID | 798956
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 798956
|
| Semantic_Type |
Amino Acid, Peptide, or Protein
Pharmacologic Substance
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| Delete | Subject | Author | Type | Created |
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