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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
| Id | http://purl.obolibrary.org/obo/NCIT_C162856
http://purl.obolibrary.org/obo/NCIT_C162856
|
|---|---|
| Preferred Name | Autologous Anti-CD19 CAR-CD28 T-cells ET019002 |
| Definitions |
A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) of anti-CD19, coupled to the costimulatory domain of CD28, with potential immunostimulating and antineoplastic activities. Upon transfusion, the autologous anti-CD19 CAR-CD28 T-cells ET019002 target, bind to, and induce selective toxicity in CD19-expressing B-cells. The CD19 antigen is a B-cell-specific cell surface antigen expressed in all B-cell lineage malignancies.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) consisting of a single chain variable fragment (scFv) of anti-CD19, coupled to the costimulatory domain of CD28, with potential immunostimulating and antineoplastic activities. Upon transfusion, the autologous anti-CD19 CAR-CD28 T-cells ET019002 target, bind to, and induce selective toxicity in CD19-expressing B-cells. The CD19 antigen is a B-cell-specific cell surface antigen expressed in all B-cell lineage malignancies. |
|---|---|
| prefLabel | Autologous Anti-CD19 CAR-CD28 T-cells ET019002
|
| label | Autologous Anti-CD19 CAR-CD28 T-cells ET019002
|
| NCI_META_CUI | CL973342
|
| PDQ_Closed_Trial_Search_ID | 798902
|
| code | C162856
|
| prefixIRI | NCIT:C162856
|
| in_subset | |
| Preferred_Name | Autologous Anti-CD19 CAR-CD28 T-cells ET019002
|
| Maps_To | Autologous Anti-CD19 CAR-CD28 T-cells ET019002
|
| NCI_Drug_Dictionary_ID | 798902
|
| type | |
| Is_Value_For_GDC_Property | |
| subClassOf | |
| PDQ_Open_Trial_Search_ID | 798902
|
| Semantic_Type |
Pharmacologic Substance
Cell
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| Delete | Subject | Author | Type | Created |
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